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CRYSTALLINS, ALPHA
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DeCS
Descriptor
English
:
alpha-Crystallins
Descriptor
Spanish
:
alfa-cristalinas
Descriptor
Portuguese
:
alfa-Cristalinas
Synonyms
English
:
Crystallins, alpha
alpha Crystallin
alpha Crystallins
alpha-Crystallin
Tree Number:
D12.776.306.366.100
D12.776.580.157
Definition
English
:
A subclass of
crystallins
that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in
VERTEBRATES
.
Alpha-crystallins
also act as
molecular chaperones
that bind to denatured
proteins
, keep them in solution and thereby maintain the translucency of the lens. The
proteins
exist as large oligomers that are formed from
ALPHA-CRYSTALLIN A CHAIN
and
ALPHA-CRYSTALLIN B CHAIN
subunits.
History Note
English
:
2003; for ALPHA-CRYSTALLIN use CRYSTALLINS 1982-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37439
Unique Identifier:
D038201
Occurrence in VHL
:
Similar:
DeCS